In the natural process of aging, elastin fibers and collagen in the skin decrease, which eventually results in skin aging, fine lines, and deep wrinkles ( 1).
#Mc jin aiya trial#
Application of CTP was well-tolerated, and no notable adverse effect was reported from both groups.ĭiscussion: Our findings suggest that oral ingestion of CTP from the Skin of Nile Tilapia ( Oreochromis niloticus) is well-tolerated and helps reduce water loss in in middle-aged women.Ĭlinical Trial Registration: Identifier: NCT03505684. In the subgroup analysis, subjects under 50 years of age showed a significant improvement in total score and moisture in the subjective skin improvement questionnaire after taking CTP for 12 weeks. In terms of skin hydration, more improvement was evident in the CTP group than in the control group. At 12 weeks, even after adjustment for humidity, temperature, and UVA in the region, the difference of the two groups in TEWL remained statistically significant (adjusted for humidity and temperature, P = 0.024 adjusted for UVA, P = 0.032 adjusted for temperature, high temperature, and ultraviolet A, P = 0.031). Compared with the control group, trans-epidermal water loss was reduced more in the CTP group after 12 weeks ( P < 0.05). Results: Of the 82 participants, 74 completed the trial without adverse effects.
Skin hydration, wrinkling, and elasticity were assessed at baseline and after 6 and 12 weeks with adjustments for temperature, humidity, and ultraviolet A exposure during the evaluation time using weather data from the regional meteorological office.
CTP was prepared from the skin of Nile Tilapia by the digestion method using collagenase from non-pathogenic bacteria of the genus Bacillus. Participants were randomized to receive placebo or 1,000 mg CTP daily for 12 weeks. Materials and Methods: A randomized controlled trial was conducted with 84 women between 40 and 60 years of age. Therefore, we tested the effect of CTP and adjusting for climate change on skin properties in middle-aged women. Moreover, the majority of the positive outcomes of CTP reported so far have not considered the effect of weather conditions. Introduction: Although collagen is widely used in various forms as a functional ingredient in skin care products, the effect of oral supplementation of collagen tripeptides (CTPs) on human skin is unclear.
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